MIMic trial – 16S rRNA gene sequencing of FMT donor and patient fecal samples

This repository contains the R scripts used for analyzing 16S rRNA gene sequencing data derived from participants in the MIMic trial (NCT03772899) - a multicenter single-arm phase I safety trial that assessed fecal microbiota transplantation (FMT) in patients with advanced cutaneous melanoma who were being treated with first-line anti-PD-1 therapy.

Quick links

• ASV counts table: MIMic_16S_asv_table.txt
• Metadata table: MIMic_metadata.txt

R Markdown walk-through

See here for the R markdown walk-through on generating figures from the human 16S rRNA gene sequencing dataset.

Publication

Routy et al. (2023). Fecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial. Nature Medicine 29, 2121–2132. https://doi.org/10.1038/s41591-023-02453-x

Contact

bdaisley [at] uoguelph [dot] ca