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CA1 interneuron: K currents (Lien et al 2002)
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NEURON mod files for K currents from the paper: Lien, et al., Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurones of rat hippocampus. J Physiol. 2002 538:405-19. Running the kinetics.hoc simulation file will show the activation and inactivation steady-states, the time constants, and a family of curves generated modeling the same protocols used for Figs.5A-6A-7A of the paper. Markers show a few of the experimental values for the time constants derived from Figs.5C-6C-7C-7D. For both the fast and slow KDR currents an inactivation time constant of 1sec is assumed. KA recovery from inactivation is not implemented. Under unix systems: to compile the mod files use the command nrnivmodl and run the simulation hoc file with the command nrngui kinetics.hoc Under Windows: to compile the mod files use the "mknrndll" command. A double click on the simulation file kinetics.hoc will open the simulation window. Questions on how to use this model with NEURON should be directed to michele@pa.ibf.cnr.it
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