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K regulation model in R used for Morris Method anlaysis

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Kreg_GSA

R version of K regulation model used for Morris Method analysis. This code was used for Stadt & Layton, A mathematical model of whole-body potassium regulation: Global parameter sensitivity analysis, preprint

Main driver files

These are the main driver files to compute simulation results and the Morris Method analysis driver_singlemeals.r Runs a baseline simulation for each of the single meal experiments (Meal + KCl, Meal Only, KCl Only).

runODEMorris_MealKCl.r Runs Morris method analysis for the Meal + KCl experiments.

runODEMorris_MealOnly.r Runs Morris method analysis for Meal Only experiments

runODEMorris_KClOnly.r Runs Morris method analysis for KCl Only experiments

runMorris_SS.r Runs Morris method analysis for steady state results

Results/

Saved results from the simulations and global sensitivity analysis in this folder. Use convert_MorrisResults.r and convert_MorrisSS.r to convert .RData results files into .csv for plotting.

Figures/

Scripts for making figures from the results

manu_figs/ Copy of figures for manuscript

results_final/ simulation and Morris analysis results used for plotting

plot_MealSims.m plot simulation results for the 3 single meal simulation types (Meal Only, KCl Only, Meal + KCl)

plot_MI_allmeal.m plot Morris Indices for all 3 single meal simulation types

plot_MorrisSS.m plot Morris analysis results for steady state

plot_Morris_KClOnly.m plot Morris analysis results for KCl Only simulations

plot_Morris_MealOnly.m plot Morris analysis results for Meal Only simulations

plot_Morris_MealKCl.m plot Morris analysis results for Meal + KCl simulations

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