diff --git a/.github/workflows/hypothesis.yaml b/.github/workflows/hypothesis.yaml
new file mode 100644
index 000000000..5462a4b97
--- /dev/null
+++ b/.github/workflows/hypothesis.yaml
@@ -0,0 +1,106 @@
+name: Slow Hypothesis CI
+on:
+  push:
+    branches:
+      - "main"
+  pull_request:
+    branches:
+      - "main"
+    types: [opened, reopened, synchronize, labeled]
+  schedule:
+    - cron: "0 0 * * *" # Daily “At 00:00” UTC
+  workflow_dispatch: # allows you to trigger manually
+
+env:
+  FORCE_COLOR: 3
+
+jobs:
+  detect-ci-trigger:
+    name: detect ci trigger
+    runs-on: ubuntu-latest
+    if: |
+      github.repository == 'zarr-developers/zarr=python'
+      && (github.event_name == 'push' || github.event_name == 'pull_request')
+    outputs:
+      triggered: ${{ steps.detect-trigger.outputs.trigger-found }}
+    steps:
+      - uses: actions/checkout@v4
+        with:
+          fetch-depth: 2
+      - uses: xarray-contrib/ci-trigger@v1
+        id: detect-trigger
+        with:
+          keyword: "[skip-ci]"
+
+  hypothesis:
+    name: Slow Hypothesis Tests
+    runs-on: "ubuntu-latest"
+    needs: detect-ci-trigger
+    if: |
+        always()
+        && (
+            (github.event_name == 'schedule' || github.event_name == 'workflow_dispatch')
+            || needs.detect-ci-trigger.outputs.triggered == 'true'
+            || contains( github.event.pull_request.labels.*.name, 'run-slow-hypothesis')
+        )
+    defaults:
+      run:
+        shell: bash -l {0}
+
+    strategy:
+      matrix:
+        python-version: ['3.11']
+        numpy-version: ['1.26']
+        dependency-set: ["optional"]
+
+    steps:
+    - uses: actions/checkout@v4
+    - name: Set up Python
+      uses: actions/setup-python@v5
+      with:
+        python-version: $PYTHON_VERSION
+        cache: 'pip'
+    - name: Install Hatch
+      run: |
+        python -m pip install --upgrade pip
+        pip install hatch
+    - name: Set Up Hatch Env
+      run: |
+        hatch env create test.py${{ matrix.python-version }}-${{ matrix.numpy-version }}-${{ matrix.dependency-set }}
+        hatch env run -e test.py${{ matrix.python-version }}-${{ matrix.numpy-version }}-${{ matrix.dependency-set }} list-env
+    # https://github.com/actions/cache/blob/main/tips-and-workarounds.md#update-a-cache
+    - name: Restore cached hypothesis directory
+      id: restore-hypothesis-cache
+      uses: actions/cache/restore@v4
+      with:
+        path: .hypothesis/
+        key: cache-hypothesis-${{ runner.os }}-${{ github.run_id }}
+        restore-keys: |
+          cache-hypothesis-
+
+    - name: Run slow Hypothesis tests
+      if: success()
+      id: status
+      run: |
+        hatch env run --env test.py${{ matrix.python-version }}-${{ matrix.numpy-version }}-${{ matrix.dependency-set }} run-hypothesis
+
+    # explicitly save the cache so it gets updated, also do this even if it fails.
+    - name: Save cached hypothesis directory
+      id: save-hypothesis-cache
+      if: always() && steps.status.outcome != 'skipped'
+      uses: actions/cache/save@v4
+      with:
+        path: .hypothesis/
+        key: cache-hypothesis-${{ runner.os }}-${{ github.run_id }}
+
+    - name: Generate and publish the report
+      if: |
+        failure()
+        && steps.status.outcome == 'failure'
+        && github.event_name == 'schedule'
+        && github.repository_owner == 'zarr-developers'
+      uses: xarray-contrib/issue-from-pytest-log@v1
+      with:
+        log-path: output-${{ matrix.python-version }}-log.jsonl
+        issue-title: "Nightly Hypothesis tests failed"
+        issue-label: "topic-hypothesis"
diff --git a/pyproject.toml b/pyproject.toml
index 80e03322a..7f61cd947 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -131,6 +131,7 @@ run-coverage = "pytest --cov-config=pyproject.toml --cov=pkg --cov=tests"
 run = "run-coverage --no-cov"
 run-verbose = "run-coverage --verbose"
 run-mypy = "mypy src"
+run-hypothesis = "pytest --hypothesis-show-statistics tests/test_properties.py"
 list-env = "pip list"
 
 [tool.hatch.envs.docs]