diff --git a/.gitignore b/.gitignore
index baab3e6d..b37e34f7 100644
--- a/.gitignore
+++ b/.gitignore
@@ -149,6 +149,7 @@ pytest.ini
 # data directories
 data/*
 therapy/data/
+src/therapy/data/*
 
 # dynamodb
 dynamodb_local_latest/*
diff --git a/pyproject.toml b/pyproject.toml
index a291b1ec..1d96166e 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -1,8 +1,74 @@
+[project]
+name = "therapy-normalizer"
+authors = [
+    {name = "Alex Wagner"},
+    {name = "Kori Kuzma"},
+    {name = "James Stevenson"}
+]
+readme = "README.md"
+classifiers = [
+    "Development Status :: 3 - Alpha",
+    "Framework :: FastAPI",
+    "Framework :: Pydantic",
+    "Framework :: Pydantic :: 2",
+    "Intended Audience :: Science/Research",
+    "Intended Audience :: Developers",
+    "Topic :: Scientific/Engineering :: Bio-Informatics",
+    "License :: OSI Approved :: MIT License",
+    "Programming Language :: Python :: 3",
+    "Programming Language :: Python :: 3.8",
+    "Programming Language :: Python :: 3.9",
+    "Programming Language :: Python :: 3.10",
+    "Programming Language :: Python :: 3.11",
+]
+requires-python = ">=3.8"
+description = "VICC normalization routines for therapeutics"
+license = {file = "LICENSE"}
+dependencies = [
+    "pydantic==2.*",
+    "fastapi",
+    "uvicorn",
+    "click",
+    "boto3",
+    "ga4gh.vrs~=2.0.0a1",
+]
+dynamic = ["version"]
+
+[project.optional-dependencies]
+etl = ["disease-normalizer~=0.4.0.dev0", "owlready2", "rdflib", "wikibaseintegrator>=0.12.0", "chembl-downloader", "bioversions>=0.4.3"]
+test = ["pytest", "pytest-cov"]
+dev = ["pre-commit", "ruff>=0.1.2", "lxml", "xmlformatter", "mypy", "types-requests", "types-pyyaml"]
+
+[project.urls]
+Homepage = "https://github.com/cancervariants/therapy-normalization"
+Documentation = "https://github.com/cancervariants/therapy-normalization"
+Changelog = "https://github.com/cancervariants/therapy-normalization/releases"
+Source = "https://github.com/cancervariants/therapy-normalization"
+"Bug Tracker" = "https://github.com/cancervariants/therapy-normalization/issues"
+
 [build-system]
-requires = ["setuptools", "wheel"]
-build-backend = "setuptools.build_meta:__legacy__"
+requires = ["setuptools>=61.0"]
+build-backend = "setuptools.build_meta"
+
+[tool.setuptools.dynamic]
+version = {attr = "therapy.version.__version__"}
+
+[tool.setuptools.packages.find]
+where = ["src"]
+
+[tool.pytest.ini_options]
+addopts = "--cov=src --cov-report term-missing"
+testpaths = ["tests"]
+
+[tool.coverage.run]
+branch = true
+
+[tool.mypy]
+plugins = "pydantic.mypy"
+ignore_missing_imports = true
 
 [tool.ruff]
+src = ["src"]
 # pycodestyle (E, W)
 # Pyflakes (F)
 # flake8-annotations (ANN)
diff --git a/setup.cfg b/setup.cfg
deleted file mode 100644
index 9e40d85a..00000000
--- a/setup.cfg
+++ /dev/null
@@ -1,65 +0,0 @@
-[metadata]
-name = thera-py
-description = VICC normalization routine for therapies
-long_description = file:README.md
-long_description_content_type = text/markdown
-url = https://github.com/cancervariants/therapy-normalization
-author = VICC
-author_email = help@cancervariants.org
-license = MIT
-
-[options]
-packages = find:
-python_requires = >=3.8
-zip_safe = False
-include_package_data = True
-
-install_requires =
-    pydantic ==2.*
-    fastapi >= 0.92.0
-    click
-    uvicorn
-    boto3
-    ga4gh.vrs ~= 2.0.0a1
-
-[options.package_data]
-therapy =
-    etl/*
-
-[options.extras_require]
-test =
-    pytest
-    pytest-cov
-
-dev =
-    disease-normalizer ~= 0.4.0.dev0
-    owlready2
-    rdflib
-    wikibaseintegrator >= 0.12.0
-    chembl-downloader
-    bioversions >= 0.4.3
-    ipykernel
-    ipython >= 8.10
-    pre-commit
-    tox
-    mypy
-    types-requests
-    types-pyyaml
-    lxml
-    xmlformatter
-    ruff >= 0.1.2
-
-[tool:pytest]
-addopts = --ignore setup.py --ignore=analysis/ --cov-report term-missing --cov=therapy
-
-[mypy]
-plugins = pydantic.mypy
-ignore_missing_imports = True
-
-[coverage:run]
-source =
-   therapy/
-   tests/
-omit =
-   setup.py
-   docs/*
diff --git a/setup.py b/setup.py
deleted file mode 100644
index 03d3083e..00000000
--- a/setup.py
+++ /dev/null
@@ -1,5 +0,0 @@
-"""Defines how metakb is packaged and distributed."""
-from setuptools import setup
-
-exec(open("therapy/version.py").read())
-setup(version=__version__)  # noqa: F821
diff --git a/therapy/__init__.py b/src/therapy/__init__.py
similarity index 100%
rename from therapy/__init__.py
rename to src/therapy/__init__.py
diff --git a/therapy/cli.py b/src/therapy/cli.py
similarity index 100%
rename from therapy/cli.py
rename to src/therapy/cli.py
diff --git a/therapy/database.py b/src/therapy/database.py
similarity index 100%
rename from therapy/database.py
rename to src/therapy/database.py
diff --git a/therapy/etl/__init__.py b/src/therapy/etl/__init__.py
similarity index 100%
rename from therapy/etl/__init__.py
rename to src/therapy/etl/__init__.py
diff --git a/therapy/etl/base.py b/src/therapy/etl/base.py
similarity index 100%
rename from therapy/etl/base.py
rename to src/therapy/etl/base.py
diff --git a/therapy/etl/chembl.py b/src/therapy/etl/chembl.py
similarity index 100%
rename from therapy/etl/chembl.py
rename to src/therapy/etl/chembl.py
diff --git a/therapy/etl/chemidplus.py b/src/therapy/etl/chemidplus.py
similarity index 100%
rename from therapy/etl/chemidplus.py
rename to src/therapy/etl/chemidplus.py
diff --git a/therapy/etl/drugbank.py b/src/therapy/etl/drugbank.py
similarity index 100%
rename from therapy/etl/drugbank.py
rename to src/therapy/etl/drugbank.py
diff --git a/therapy/etl/drugsatfda.py b/src/therapy/etl/drugsatfda.py
similarity index 100%
rename from therapy/etl/drugsatfda.py
rename to src/therapy/etl/drugsatfda.py
diff --git a/therapy/etl/guidetopharmacology.py b/src/therapy/etl/guidetopharmacology.py
similarity index 100%
rename from therapy/etl/guidetopharmacology.py
rename to src/therapy/etl/guidetopharmacology.py
diff --git a/therapy/etl/hemonc.py b/src/therapy/etl/hemonc.py
similarity index 100%
rename from therapy/etl/hemonc.py
rename to src/therapy/etl/hemonc.py
diff --git a/therapy/etl/merge.py b/src/therapy/etl/merge.py
similarity index 100%
rename from therapy/etl/merge.py
rename to src/therapy/etl/merge.py
diff --git a/therapy/etl/ncit.py b/src/therapy/etl/ncit.py
similarity index 100%
rename from therapy/etl/ncit.py
rename to src/therapy/etl/ncit.py
diff --git a/therapy/etl/rules.csv b/src/therapy/etl/rules.csv
similarity index 100%
rename from therapy/etl/rules.csv
rename to src/therapy/etl/rules.csv
diff --git a/therapy/etl/rules.py b/src/therapy/etl/rules.py
similarity index 100%
rename from therapy/etl/rules.py
rename to src/therapy/etl/rules.py
diff --git a/therapy/etl/rxnorm.py b/src/therapy/etl/rxnorm.py
similarity index 100%
rename from therapy/etl/rxnorm.py
rename to src/therapy/etl/rxnorm.py
diff --git a/therapy/etl/wikidata.py b/src/therapy/etl/wikidata.py
similarity index 100%
rename from therapy/etl/wikidata.py
rename to src/therapy/etl/wikidata.py
diff --git a/therapy/main.py b/src/therapy/main.py
similarity index 100%
rename from therapy/main.py
rename to src/therapy/main.py
diff --git a/therapy/query.py b/src/therapy/query.py
similarity index 100%
rename from therapy/query.py
rename to src/therapy/query.py
diff --git a/therapy/schemas.py b/src/therapy/schemas.py
similarity index 100%
rename from therapy/schemas.py
rename to src/therapy/schemas.py
diff --git a/therapy/version.py b/src/therapy/version.py
similarity index 100%
rename from therapy/version.py
rename to src/therapy/version.py