diff --git a/Pipfile b/Pipfile
index e5abbaa..d9abebd 100644
--- a/Pipfile
+++ b/Pipfile
@@ -9,7 +9,7 @@ fastapi = "*"
 uvicorn = "*"
 click = "*"
 boto3 = "*"
-"ga4gh.vrs" = "~=2.0.0a8"
+"ga4gh.vrs" = "~=2.0.0a10"
 
 [dev-packages]
 gene = {editable = true, path = "."}
diff --git a/pyproject.toml b/pyproject.toml
index ebd7d5f..af6d18a 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -29,7 +29,7 @@ dependencies = [
     "uvicorn",
     "click",
     "boto3",
-    "ga4gh.vrs~=2.0.0a8",
+    "ga4gh.vrs~=2.0.0a10",
 ]
 dynamic = ["version"]