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cells.hoc.txt
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cells.hoc.txt
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/* 4-compartment model of a deep layer PFC pyramidal cell */
/* from Durstewitz et al. (2000), J.Neurophysiol. 83: 1733-50 */
/* Modified paramaters from the same paper to simulate DA perturbation */
nrn_load_dll("./x86_64/.libs/libnrnmech.so")
begintemplate Pyramidal
public soma, basal, prox, dist
create soma, basal, prox, dist
proc init() {
rGeo = $1
rCm = $2
rR = $3
DA = $4
cao0_ca_ion = 2 /* mM */
cai0_ca_ion = 50e-6 /* mM */
ko0_k_ion = 3.82 /* mM */
ki0_k_ion = 140 /* mM */
celcius = 23
soma {
nseg=1
L=23.0*rGeo
diam=23.0*rGeo
insert Naf
gnafbar_Naf = 0.086
insert NapDA
gnapbar_NapDA = 0.0022
DA_NapDA = DA
insert Hva
ghvabar_Hva = (0.00034-0.000068*DA)
insert kdr
gkdrbar_kdr = 0.0338
insert IKs
gKsbar_IKs = (0.00014-0.00007*DA)
insert iC
gkcbar_iC = 0.0022
insert cadyn
CAF_cadyn = 385.948e-9
tca_cadyn = 250
insert kdyn
insert pas
e_pas = -70
Ra = 150*rR
g_pas = 3.33e-5
cm = 1.2*rCm
}
basal {
nseg=1
L=150.0*rGeo
diam=16.0
insert Naf
gnafbar_Naf = 0.028
insert NapDA
gnapbar_NapDA = 0.001
DA_NapDA = DA
insert Hva
ghvabar_Hva = (0.0007-0.00014*DA)
insert kdr
gkdrbar_kdr = 0.0092
insert IKs
gKsbar_IKs = (0.00024-0.00012*DA)
insert iC
gkcbar_iC = 0.0038
insert cadyn
CAF_cadyn=964.87e-9
tca_cadyn =120
insert kdyn
insert pas
cm = 2.3*rCm
g_pas = 6.39e-5
e_pas = -70
Ra = 150*rR
}
prox {
nseg=1
L=400.0*rGeo
diam=2.6
insert Naf
gnafbar_Naf = 0.028
insert NapDA
gnapbar_NapDA = 0.001
DA_NapDA = DA
insert Hva
ghvabar_Hva = (0.0007-0.00014*DA)
insert kdr
gkdrbar_kdr = 0.0092
insert IKs
gKsbar_IKs = (0.00024-0.00012*DA)
insert iC
gkcbar_iC = 0.0038
insert cadyn
CAF_cadyn = 964.87e-9
tca_cadyn = 120
insert kdyn
insert pas
cm = 2.3*rCm
g_pas = 6.39e-5
e_pas = -70
Ra = 150*rR
}
dist {
nseg=1
L=400*rGeo
diam=2.6
insert Naf
gnafbar_Naf = 0.028
insert Hva
ghvabar_Hva = (0.00034-0.00017*DA)
insert kdr
gkdrbar_kdr = 0.0092
insert IKs
gKsbar_IKs = (0.00024-0.00012*DA)
insert iC
gkcbar_iC = 0.0022
insert cadyn
CAF_cadyn = 964.87e-9
tca_cadyn = 80
insert kdyn
insert pas
cm = 2.3*rCm
g_pas = 6.39e-5
e_pas = -70
Ra = 150*rR
}
connect basal(0), soma(0)
connect prox(0), soma(1)
connect dist(0), prox(1)
}
public set_v
proc set_v() {
forall v = $1
}
public set_DA
proc set_DA() {
DA = $1
soma {
ghvabar_Hva = (0.00034-0.000068*DA)
gKsbar_IKs = (0.00014-0.00007*DA)
DA_NapDA = DA
}
basal {
ghvabar_Hva = (0.0007-0.00014*DA)
gKsbar_IKs = (0.00024-0.00012*DA)
DA_NapDA = DA
}
prox {
insert Hva
ghvabar_Hva = (0.0007-0.00014*DA)
gKsbar_IKs = (0.00024-0.00012*DA)
DA_NapDA = DA
}
dist {
ghvabar_Hva = (0.00034-0.00017*DA)
gKsbar_IKs = (0.00024-0.00012*DA)
}
}
endtemplate Pyramidal
begintemplate Interneuron
public soma, dendrite
create soma, dendrite
proc init() {
rGeo = $1
rCm = $2
rR = $3
DA = $4
ko0_k_ion = 3.82 /* mM */
ki0_k_ion = 140 /* mM */ nseg=1
soma {
L=15.0*rGeo
diam=15.0*rGeo
insert Naf_fs
gnafbar_Naf_fs = 0.100
insert kdr_fs
gkdrbar_kdr_fs = 0.040
insert kdyn
insert pas
cm = 1.0 /* microF/cm2 */
g_pas = 10.00*1e-5 /* mho/cm2 */
e_pas = -70
Ra = 150*rR /* ohm-cm */
}
dendrite {
L=150.0*rGeo
diam=10.0
insert Naf_fs
gnafbar_Naf_fs = 0.020
insert kdr_fs
gkdrbar_kdr_fs = 0.008
insert kdyn
insert pas
cm = 1.0*rCm /* microF/cm2 */
g_pas = 10.00*1e-5 /* mho/cm2 */
e_pas = -70
Ra = 150*rR /* ohm-cm */
}
connect dendrite(0), soma(0)
}
public set_v
proc set_v() {
forall v = $1
}
public set_DA
proc set_DA() {
DA = $1
soma {
g_pas = (10.00-0.0*DA)*1e-5 /* mho/cm2 */
}
dendrite {
g_pas = (10.00-0.0*DA)*1e-5 /* mho/cm2 */
}
}
endtemplate Interneuron