-
Notifications
You must be signed in to change notification settings - Fork 0
/
ALS_SBML_draft_v1-002.xml
531 lines (478 loc) · 23.6 KB
/
ALS_SBML_draft_v1-002.xml
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
481
482
483
484
485
486
487
488
489
490
491
492
493
494
495
496
497
498
499
500
501
502
503
504
505
506
507
508
509
510
511
512
513
514
515
516
517
518
519
520
521
522
523
524
525
526
527
528
529
530
531
<?xml version='1.0' encoding='UTF-8' standalone='no'?>
<sbml xmlns="http://www.sbml.org/sbml/level2/version4" level="2" metaid="c4124f17-ac90-4ca4-be1d-2fe34c562a24" version="4">
<model name="JPLeRouzic2018 - Interaction between astrocytes and neurons in Amyotrophic lateral sclerosis (ALS)" id="MODEL_to_be_done">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<div class="dc:title">JPLeRouzic2018 - Interactions between astrocytes
and neurons in Amyotrophic lateral sclerosis (ALS)</div>
<div class="dc:description">Encoded non-curated model. Issues: <br>To be done</br>
</div>
<div class="dc:bibliographicCitation"> <p>This model is described in the article:</p>
<div class="bibo:title"> <a href="http://identifiers.org/pubmed/20552235" title="Access to this publication">Motor neuron-immune interactions: The vicious circle of ALS.</a>
</div>
<div class="bibo:authorList">Barbeito AG, Mesci P, Boillée S.</div>
<div class="bibo:Journal">J Neural Transm (Vienna). 2010 Aug;117(8):981-1000.</div>
<p>Abstract:</p>
<div class="bibo:abstract"> <p>Because microglial cells, the resident macrophages of the CNS, react to any lesion of the nervous system, <br/>
they have for long been regarded as potential players in the pathogenesis of several neurodegenerative disorders including amyotrophic lateral sclerosis, <br/>
the most common motor neuron disease in the adult. <br/>
In recent years, this microglial reaction to motor neuron injury, in particular, and the innate immune response, in general, <br/>
has been implicated in the progression of the disease, in mouse models of ALS. <br/>
The mechanisms by which microglial cells influence motor neuron death in ALS are still largely unknown. <br/>
Microglial activation increases over the course of the disease and is associated with an alteration in the production of toxic factors and also <br/>
neurotrophic factors. <br/>
Adding to the microglial/macrophage response to motor neuron degeneration, the adaptive immune system can likewise influence the disease process. <br/>
Exploring these motor neuron-immune interactions could lead to a better understanding in the physiopathology of ALS to find <br/>
new pathways to slow down motor neuron degeneration. </p>
</div>
<div class="dc:publisher"> <p>This model will be hosted on <a href="http://www.ebi.ac.uk/biomodels/">BioModels Database</a>
and identified by: <a href="http://identifiers.org/biomodels.db/MODELtobedone">MODEL-to-be-done</a>
. </p>
<p>To cite BioModels Database, please use: <a href="http://identifiers.org/pubmed/20587024" title="Latest BioModels Database publication">BioModels Database:
An enhanced, curated and annotated resource for published
quantitative kinetic models</a>
. </p>
</div>
<div class="dc:license"> <p>To the extent possible under law, all copyright and related or
neighbouring rights to this encoded model have been dedicated to
the public domain worldwide. Please refer to <a href="http://creativecommons.org/publicdomain/zero/1.0/" title="Access to: CC0 1.0 Universal (CC0 1.0), Public Domain Dedication">CC0
Public Domain Dedication</a>
for more information. </p>
</div>
</div>
</body>
</notes>
<listOfUnitDefinitions>
<unitDefinition name="volume" id="volume" metaid="_38ba8c9f-937c-475c-813f-aa6ade0b1845">
<listOfUnits>
<unit scale="-3" metaid="a9cd72a6-2891-4f4a-99ce-1de794afd9c0" kind="litre" multiplier="1" exponent="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition name="time" id="time" metaid="_79bb7d94-2052-4d38-801e-f2de2f2cf67a">
<listOfUnits>
<unit scale="0" metaid="d517ee51-ff20-4f36-89a5-72cc7414e9c1" kind="second" exponent="1"/>
</listOfUnits>
</unitDefinition>
<unitDefinition name="substance" id="substance" metaid="_45963f6f-46e8-415f-83b9-f4ff8374d6fb">
<listOfUnits>
<unit scale="0" metaid="_80760473-3d2d-49a5-853b-c0db9933eb5d" kind="dimensionless" multiplier="1" exponent="1"/>
</listOfUnits>
</unitDefinition>
</listOfUnitDefinitions>
<listOfCompartments>
<compartment constant="true" size="1" metaid="COPASI1" name="CentralNervousSystem" id="CentralNervousSystem" spatialDimensions="3"/>
<compartment constant="true" size="0.2" metaid="_9900a077-72fa-46e3-9b6c-81856a5bdb48" name="Extracellular space" id="Extracellular_space" spatialDimensions="3"/>
<compartment constant="true" size="0.0055" metaid="_15807251-6568-48ac-8f23-b56570441672" name="Capillaries" id="Capillaries" spatialDimensions="3"/>
<compartment constant="true" size="0.0237" metaid="dd33450c-6095-4d8e-9482-3ad351480412" name="Veins" id="Veins" spatialDimensions="3"/>
</listOfCompartments>
<listOfSpecies>
<!--
<species boundaryCondition="true" constant="false" metaid="COPASI211" hasOnlySubstanceUnits="false" compartment="CentralNervousSystem" name="PreSynapticNeurons" id="PreSynapticNeurons" initialConcentration="999999">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<pre>Pre-Synaptic Neurons</pre>
</body>
</notes>
</species>
<species boundaryCondition="true" constant="false" metaid="COPASI212" hasOnlySubstanceUnits="false" compartment="CentralNervousSystem" name="Exocytosis" id="Exocytosis" initialConcentration="999999">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<pre>Exocytosis</pre>
</body>
</notes>
</species>
<species boundaryCondition="true" constant="false" metaid="COPASI213" hasOnlySubstanceUnits="false" compartment="CentralNervousSystem" name="BrokenMotorUnit" id="BrokenMotorUnit" initialConcentration="1">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
A motor unit is made up of a motor neuron and the skeletal muscle fibers innervated by that motor neuron's axonal terminals.<br/>
Groups of motor units often work together to coordinate the contractions of a single muscle.<br/>
All of the motor units within a muscle are considered a motor pool. </body>
</notes>
</species>
<species boundaryCondition="true" constant="false" metaid="COPASI214" hasOnlySubstanceUnits="false" compartment="CentralNervousSystem" name="LivingUpperMotoNeurons" id="LivingUpperMotoNeurons" initialConcentration="999999">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
Surviving Upper neurons<br/>
Upper motor neurons are found in the brain and carry motor information down the spinal cord to activate the lower motor neurons,
</body>
</notes>
</species>
<species boundaryCondition="true" constant="false" metaid="COPASI311" hasOnlySubstanceUnits="false" compartment="CentralNervousSystem" name="DeadUpperMotoNeurons" id="DeadUpperMotoNeurons" initialConcentration="1">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
Dead Upper neurons<br/>
Upper motor neurons are found in the brain and carry motor information down the spinal cord to activate the lower motor neurons,
</body>
</notes>
</species>
-->
<species boundaryCondition="true" constant="false" metaid="COPASI215" hasOnlySubstanceUnits="false" compartment="CentralNervousSystem" name="LivingLowerMotoNeurons" id="LivingLowerMotoNeurons" initialConcentration="999999">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
Surviving lower motor neurons<br/>
The efferent fiber carries nerve impulses away from the the spinal cord, and toward the muscles.<br/>
</body>
</notes>
</species>
<species boundaryCondition="true" constant="false" metaid="COPASI312" hasOnlySubstanceUnits="false" compartment="CentralNervousSystem" name="DeadLowerMotoNeurons" id="DeadLowerMotoNeurons" initialConcentration="1">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
Dead lower motor neurons<br/>
The efferent fiber carries nerve impulses away from the the spinal cord, and toward the muscles.<br/>
</body>
</notes>
</species>
<species boundaryCondition="true" constant="false" hasOnlySubstanceUnits="false" compartment="CentralNervousSystem" name="EAAT2Transporters" id="EAAT2Transporters" initialConcentration="200000">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
* In a healthy situation the presynaptic neuron releases glutamate (Glu), which binds to<br/>
glutamate receptors (GluRs) on the postsynaptic motor neuron, resulting in excitation through<br/>
calcium influx.<br/>
Extracellular glutamate is quickly cleared from the synaptic cleft by astrocytes through EAAT2 transporters. <br/>
* In an ALS situation decreased expression of astrocytic glutamate<br/>
transporters EAAT2 could lead to prolonged glutamate excitation of motor neurons and<br/>
participate in their degeneration (excitotoxic hypothesis)<br/>
</body>
</notes>
</species>
<!--
<species boundaryCondition="true" constant="false" metaid="COPASI411" hasOnlySubstanceUnits="false" compartment="CentralNervousSystem" name="Non_Inflammatory_Astroglia" id="Non_Inflammatory_Astroglia" initialConcentration="200">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<pre>Quiescent astroglia</pre>
</body>
</notes>
</species>
-->
<species boundaryCondition="true" constant="false" metaid="COPASI511" hasOnlySubstanceUnits="false" compartment="CentralNervousSystem" name="Pro_Inflammatory_Astroglia" id="Pro_Inflammatory_Astroglia" initialConcentration="50">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<pre>Proliferating astroglia</pre>
</body>
</notes>
</species>
<species boundaryCondition="true" constant="false" metaid="COPASI611" hasOnlySubstanceUnits="false" compartment="CentralNervousSystem" name="Anti_Inflammatory_Microglia" id="Anti_Inflammatory_Microglia" initialConcentration="200">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<pre>Normal microglia</pre>
</body>
</notes>
</species>
<species boundaryCondition="true" constant="false" metaid="COPASI711" hasOnlySubstanceUnits="false" compartment="CentralNervousSystem" name="Pro_Inflammatory_Microglia" id="Pro_Inflammatory_Microglia" initialConcentration="50">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<pre>Reactive microglia</pre>
</body>
</notes>
</species>
<!--
<species boundaryCondition="true" constant="false" metaid="COPASI2511" hasOnlySubstanceUnits="false" compartment="CentralNervousSystem" name="Monocyte" id="Monocyte" initialConcentration="1">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
They are the largest type of leukocyte and can differentiate into macrophages and myeloid lineage dendritic cells.<br/>
Monocytes can differentiate into dendritic cells by adding the cytokines granulocyte macrophage colony-stimulating factor (GM-CSF) and interleukin 4.
</body>
</notes>
</species>
<species boundaryCondition="true" constant="false" metaid="COPASI2211" hasOnlySubstanceUnits="false" compartment="CentralNervousSystem" name="B_Cell" id="B_Cell" initialConcentration="1">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
B cells, also known as B lymphocytes, are a type of white blood cell.<br/>
* They secrete antibodies.<br/>
* B cells are also classified as professional antigen-presenting cells (APCs)).<br/>
* B cells secrete cytokines.<br/>
</body>
</notes>
</species>
<species boundaryCondition="true" constant="false" metaid="COPASI2212" hasOnlySubstanceUnits="false" compartment="CentralNervousSystem" name="T_Cell" id="T_Cell" initialConcentration="1">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
T cell, or T lymphocyte, is a type of lymphocyte that plays a central role in cell-mediated immunity.<br/>
They mature in the thymus which "selects for" T cells capable of interacting with MHC, and kill the "non-self" cells.<br/>
On can further categorize T cells in:<br/>
* Cytotoxic T cells (CD8+ T cells)<br/>
* Helper T cells (CD4+ T cells)<br/>
* Regulatory T cells<br/>
* Natural Killer T cells
</body>
</notes>
</species>
<species boundaryCondition="true" constant="false" metaid="COPASI2213" hasOnlySubstanceUnits="false" compartment="CentralNervousSystem" name="DentriticCell" id="DentriticCell" initialConcentration="1">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
Dendritic cells are antigen-presenting cells. They process ("eat") material found in the ECM and present it to the T cells.<br/>
They act as messengers between the innate and the adaptive immune systems.
</body>
</notes>
</species>
-->
<species boundaryCondition="true" constant="false" metaid="COPASI2311" hasOnlySubstanceUnits="false" compartment="CentralNervousSystem" name="Cytokines" id="Cytokines" initialConcentration="1">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<pre>Cytokines</pre>
</body>
</notes>
</species>
<species boundaryCondition="true" constant="false" hasOnlySubstanceUnits="false" compartment="CentralNervousSystem" name="CD4_T_Lymphocytes" id="CD4_T_Lymphocytes" initialConcentration="0">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<pre>CD4 T_Lymphocytes generated mostly because of dying neurons.</pre>
</body>
</notes>
</species>
<species boundaryCondition="true" constant="false" hasOnlySubstanceUnits="false" compartment="CentralNervousSystem" name="CD8_T_Lymphocytes" id="CD8_T_Lymphocytes" initialConcentration="0">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<pre>CD8 T_Lymphocytes generated mostly because of dying neurons.</pre>
</body>
</notes>
</species>
<species boundaryCondition="true" constant="false" metaid="COPASI711" hasOnlySubstanceUnits="false" compartment="CentralNervousSystem" name="ToxicFactors_Astroglia" id="ToxicFactors_Astroglia" initialConcentration="0">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<pre>Toxic Factors generated by Astroglia, PGE2 and ROS.</pre>
</body>
</notes>
</species>
<species boundaryCondition="true" constant="false" hasOnlySubstanceUnits="false" compartment="CentralNervousSystem" name="ToxicFactors_Microglia" id="ToxicFactors_Microglia" initialConcentration="0">
<notes>
<body xmlns="http://www.w3.org/1999/xhtml">
<pre>Toxic Factors generated by Microglia, PGE2, IL-x, TNF, ROS and NO.</pre>
</body>
</notes>
</species>
<!-- Metabolism -->
</listOfSpecies>
<listOfParameters>
<parameter name="prmDeadNeurons" constant="true" id="prmDeadNeurons" value="1">
<notes>
Dead neurons
</notes>
</parameter>
<parameter name="prmLivingNeurons" constant="true" id="prmLivingNeurons" value="0.5">
<notes>
Living neurons
</notes>
</parameter>
<parameter name="prmCD8TLymphToDeadNeuron" constant="true" id="prmCD8TLymphToDeadNeuron" value="0.08">
<notes>
Pro Inflammatory Microglia
</notes>
</parameter>
<parameter name="prmAntiInflamMicroglia" constant="true" id="prmAntiInflamMicroglia" value="1">
<notes>
Anti Inflammatory Microglia
</notes>
</parameter>
<parameter name="prmProInflamMicroglia" constant="true" id="prmProInflamMicroglia" value="0">
<notes>
Pro Inflammatory Microglia
</notes>
</parameter>
<parameter name="prmCD4TLymphToDeadNeuron" constant="true" id="prmCD4TLymphToDeadNeuron" value="1">
<notes>
Pro Inflammatory Astroglia
</notes>
</parameter>
<parameter name="prmNonInflamAstroglia" constant="true" id="prmNonInflamAstroglia" value="0.5">
<notes>
Quiescent astroglia
</notes>
</parameter>
<parameter name="prmTxcAstroglia" constant="true" id="prmTxcAstroglia" value="16">
<notes>
Toxic output from astroglia
</notes>
</parameter>
<parameter name="prmTxcMicroglia" constant="true" id="prmTxcMicroglia" value="1">
<notes>
Toxic output from microglia
</notes>
</parameter>
<parameter name="prmCD4Lymphocytes" constant="true" id="prmCD4Lymphocytes" value="0.5">
<notes>
Controls the production of CD4 T_Lymphocytes in a dependency with the number of dying neurons
</notes>
</parameter>
<parameter name="prmCD8Lymphocytes" constant="true" id="prmCD8Lymphocytes" value="0.5">
<notes>
Controls the production of CD8 T_Lymphocytes in a dependency with the number of dying neurons
</notes>
</parameter>
<parameter name="Nb of neurons" id="NbOfNeurons" value="1000000">
<notes>
</notes>
</parameter>
<parameter name="Nb of microglia" id="NbOfMicroglia" value="100000">
<notes>
</notes>
</parameter>
<parameter name="Nb of astrocytes" id="NbOfAstrocytes" value="200000">
<notes>
</notes>
</parameter>
<!-- Metabolism -->
</listOfParameters>
<listOfRules>
<rateRule variable="DeadLowerMotoNeurons" metaid="db19c551-9a1b-4c4f-a22b-5cb828b14a48">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<!--
2018/9/14
<apply>
<times/>
<ci> NbOfNeurons </ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<ci> prmCD4TLymphToDeadNeuron </ci>
<ci> Pro_Inflammatory_Astroglia </ci>
</apply>
<apply>
<times/>
<ci> prmCD8TLymphToDeadNeuron </ci>
<ci> Pro_Inflammatory_Microglia </ci>
</apply>
</apply>
<apply>
<plus/>
<ci> NbOfAstrocytes </ci>
<ci> NbOfMicroglia </ci>
</apply>
</apply>
</apply>
-->
<apply>
<times/>
<ci> NbOfNeurons </ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<ci> prmCD4TLymphToDeadNeuron </ci>
<ci> CD4_T_Lymphocytes </ci>
</apply>
<apply>
<times/>
<ci> prmCD8TLymphToDeadNeuron </ci>
<ci> CD8_T_Lymphocytes </ci>
</apply>
</apply>
<apply>
<plus/>
<ci> NbOfAstrocytes </ci>
<ci> NbOfMicroglia </ci>
</apply>
</apply>
</apply>
</math>
</rateRule>
<rateRule variable="LivingLowerMotoNeurons" metaid="c7b7bcea-1097-42ef-8111-4023cebc0e75">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<ci> DeadLowerMotoNeurons </ci>
</apply>
</math>
</rateRule>
<rateRule variable="EAAT2Transporters" >
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<apply>
<times/>
<ci> prmProInflamMicroglia </ci>
<ci> Pro_Inflammatory_Microglia </ci>
</apply>
<apply>
<times/>
<ci> prmAntiInflamMicroglia </ci>
<ci> Anti_Inflammatory_Microglia </ci>
</apply>
</apply>
</math>
</rateRule>
<rateRule variable="Pro_Inflammatory_Astroglia" metaid="_788b482c-008b-4d79-95da-96efe85f6032">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci> DeadLowerMotoNeurons </ci>
</math>
</rateRule>
<rateRule variable="Pro_Inflammatory_Microglia" metaid="_88860791-365a-4268-9a37-235173f8db38">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<ci> DeadLowerMotoNeurons </ci>
</math>
</rateRule>
<rateRule variable="Anti_Inflammatory_Microglia" metaid="fbad149e-46be-407f-97b8-f2f451c5fb42">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<minus/>
<ci> EAAT2Transporters </ci>
<ci> DeadLowerMotoNeurons </ci>
</apply>
</math>
</rateRule>
<rateRule variable="CD4_T_Lymphocytes">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> prmCD4Lymphocytes </ci>
<ci> ToxicFactors_Astroglia </ci>
</apply>
</math>
</rateRule>
<rateRule variable="CD8_T_Lymphocytes">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> prmCD8Lymphocytes </ci>
<ci> ToxicFactors_Astroglia </ci>
</apply>
</math>
</rateRule>
<rateRule variable="ToxicFactors_Astroglia">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> prmTxcAstroglia </ci>
<apply>
<divide/>
<ci> Pro_Inflammatory_Astroglia </ci>
<ci> NbOfAstrocytes </ci>
</apply>
</apply>
</math>
</rateRule>
<rateRule variable="ToxicFactors_Microglia">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> prmTxcMicroglia </ci>
<apply>
<divide/>
<ci> Pro_Inflammatory_Microglia </ci>
<ci> NbOfMicroglia </ci>
</apply>
</apply>
</math>
</rateRule>
<rateRule variable="Cytokines">
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<times/>
<ci> prmTxcMicroglia </ci>
<apply>
<divide/>
<ci> Pro_Inflammatory_Microglia </ci>
<ci> NbOfMicroglia </ci>
</apply>
</apply>
</math>
</rateRule>
<!-- Part about metabolism -->
</listOfRules>
</model>
</sbml>